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Base editing, a derivative of CRISPR, allows direct conversion of one DNA base to another without causing ________.
- Mutations
- Double-strand breaks
- Deletions
- Insertions
Answer: Double-strand breaks
Base editors (e.g., cytosine/adenine base editors) chemically convert C→T or A→G without DSBs, reducing unintended indels. Safer for therapeutic genome editing. [[DBT Reports, NCERT Biology Class 12]]